Ralph Burton is a miner who is trapped for several days as a result of a cave-in. When he finally manages to dig himself out, he realizes that all of mankind seems to have been destroyed in a nuclear holocaust. He travels to New York City only to find it deserted. Making a life for himself there, he is flabbergasted to eventually find Sarah Crandall, who also managed to survive. Together, they form a close friendship until the arrival of Benson Thacker who has managed to pilot his small boat into the city's harbor. At this point the tensions rise between the three, particularly between Thacker, who is white and Burton, who is black.
Amid picturesque red dirt, blue sky, and green agave fields stands Dos Estaciones, a once-majestic tequila factory struggling to stay afloat. At the helm of the plant reigns Maria Garcia, heir to the family business and beacon to the townspeople she employs. To help oversee the company’s administration, Maria appoints an eager woman named Rafaela, whose vibrant presence generates much-needed hope in a home thirsty for a miracle. When a persistent plague and an unexpected flood cause irreversible damage, Maria is forced to do everything she can to save her community’s main source of economy and pride.